fragile X syndrome
noun
variants
or less commonly fragile X
: an X-linked inherited disorder that is characterized especially by moderate to severe intellectual and developmental disabilities, an elongated face and prominent forehead, chin, and ears, and by large testes in males, and that often has limited or no effect in heterozygous females
… most children with fragile X syndrome have other characteristic traits, including anxiety, hyperactivity, and a number of behaviors that are often seen in autism.—
Mark Cohen
Mark CohenThe defective gene responsible for fragile X syndrome is carried on one leg of the X chromosome, the chromosome that helps determine the sex of a child.—Elaine T. Cicora
Elaine T. CicoraFemale carriers of fragile X syndrome as a group exhibit wide variation in degree of phenotypic involvement. Some heterozygotes are cognitively unaffected, others have learning disabilities, and approximately one third have significant mental impairment and an IQ score of less than 85.—Annette K. Taylor et al.
Annette K. Taylor et al.Examples of fragile X syndrome in a Sentence
Recent Examples on the Web
Having 200 or more CGG repeats silences the FMR1 gene and results in fragile X syndrome.
—Joel Richter, The Conversation, 26 July 2023
Beyond mice models Notably, fragile X syndrome is most often studied using mouse models.
—Joel Richter, The Conversation, 26 July 2023
In the United States today, pregnant women can find out whether their unborn child has cystic fibrosis, fragile X syndrome, spinal muscular atrophy, or many other conditions.
—Krithika Varagur, Harper's Magazine, 10 July 2023
But researchers have already delivered a gene for the protein missing in fragile X syndrome to mouse models of the condition.
—Lydia Denworth, Science | AAAS, 14 Oct. 2020
Turner syndrome, fragile X syndrome, Prader-Willi syndrome, and other severe genetic disorders.
—Jessie Balmert, The Enquirer, 2 Mar. 2021
The gene linked to fragile X syndrome lies on the X chromosome.
—Emily Willingham, Discover Magazine, 18 Apr. 2019
Developing gene therapies for diseases that affect the central nervous system, including giant axonal neuropathy, Rett syndrome, and fragile X syndrome.
—Ann Gehan, Dallas News, 2 Sep. 2021
Those with severe genetic disorders including Down syndrome, fragile X syndrome, Prader-Willi syndrome, Turner syndrome and muscular dystrophy.
—Jessie Balmert, The Enquirer, 22 Mar. 2021
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Joel Richter, The Conversation, 26 July 2023
Beyond mice models Notably, fragile X syndrome is most often studied using mouse models.
—Joel Richter, The Conversation, 26 July 2023
In the United States today, pregnant women can find out whether their unborn child has cystic fibrosis, fragile X syndrome, spinal muscular atrophy, or many other conditions.
—Krithika Varagur, Harper's Magazine, 10 July 2023
But researchers have already delivered a gene for the protein missing in fragile X syndrome to mouse models of the condition.
—Lydia Denworth, Science | AAAS, 14 Oct. 2020
Turner syndrome, fragile X syndrome, Prader-Willi syndrome, and other severe genetic disorders.
—Jessie Balmert, The Enquirer, 2 Mar. 2021
The gene linked to fragile X syndrome lies on the X chromosome.
—Emily Willingham, Discover Magazine, 18 Apr. 2019
Developing gene therapies for diseases that affect the central nervous system, including giant axonal neuropathy, Rett syndrome, and fragile X syndrome.
—Ann Gehan, Dallas News, 2 Sep. 2021
Those with severe genetic disorders including Down syndrome, fragile X syndrome, Prader-Willi syndrome, Turner syndrome and muscular dystrophy.
—Jessie Balmert, The Enquirer, 22 Mar. 2021
Dictionary Entries Near fragile X syndrome
Cite this Entry
“Fragile X syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fragile%20X%20syndrome. Accessed 23 Nov. 2024.
Copy CitationMedical Definition
fragile X syndrome
noun
variants
also fragile X
: an X-linked inherited disorder that is caused by repeats of a trinucleotide sequence on the X chromosome which are abnormal in number and degree of methylation, that is characterized especially by moderate to severe intellectual and developmental disabilities, an elongated face and prominent forehead, chin, and ears, and by enlarged testes in males, and that often has limited or no effect in heterozygous females
Female carriers of fragile X syndrome as a group exhibit wide variation in degree of phenotypic involvement. Some heterozygotes are cognitively unaffected, others have learning disabilities, and approximately one third have significant mental impairment and an IQ score of less than 85.—Annette K. Taylor et al., The Journal of the American Medical Association
Annette K. Taylor et al., The Journal of the American Medical AssociationIn approximately 10% of patients, autism can be explained by genetic syndromes and known chromosomal anomalies (most of which have recognizable features in addition to autism), including the fragile X syndrome, tuberous sclerosis, … and maternally inherited duplications of the region that is affected in the Prader-Willi and Angelman syndromes.—Lauren A. Weiss et al., The New England Journal of Medicine
Lauren A. Weiss et al., The New England Journal of MedicineLove words? Need even more definitions?
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