monoclonal antibody

noun

plural monoclonal antibodies
: an antibody that is derived from the clone of a single B cell and that is produced in large quantities of identical cells possessing affinity for the same epitope on a specific antigen (as a cancer cell)

Note: Monoclonal antibodies are typically used in immunotherapy (such as in the treatment of autoimmune or inflammatory disorders and cancer), diagnostic testing, and cell identification and tracing. Hybridoma cell lines are typically employed to produce an unlimited supply of monoclonal antibodies.

Researchers studying this and other cancers have long sought to use monoclonal antibodies—biological molecules that bind only to particular target cells—to attack tumors directly or to shuttle toxins selectively to cancer cells.—R. Weiss
The ideal immunosuppressive monoclonal antibody would be one that abrogates responses to a defined antigen and preserves responses to all others.—Thomas A. Waldmann
The drug, which would be given by intravenous infusion every four weeks, is a monoclonal antibody that tamps down the immune system …—Andrew Pollack
—abbreviation Mab, mAb, MAB, mab

Examples of monoclonal antibody in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Importantly, there are two monoclonal antibodies that are already approved by the FDA which can block IL-1 signaling. —Michael Irving, New Atlas, 4 Nov. 2024 The treatments are monoclonal antibody infusions, given every two or four weeks and are costly — $26,500 to $32,000 per patient per year. —Linda Carroll, NBC News, 1 Nov. 2024 Both are monoclonal antibodies, which deliver antibodies directly into the bloodstream to provide immediate protection. —Annika Kim Constantino, CNBC, 17 Oct. 2024 Their toxic tau conformation-specific monoclonal antibody 2 (TTCM2) specifically detects and targets disease-relevant tau aggregates. —New Atlas, 23 July 2024 See all Example Sentences for monoclonal antibody 

Word History

First Known Use

1967, in the meaning defined above

Time Traveler
The first known use of monoclonal antibody was in 1967

Dictionary Entries Near monoclonal antibody

monoclonal

monoclonal antibody

monoclonal gammopathy

See More Nearby Entries 

Cite this Entry

“Monoclonal antibody.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/monoclonal%20antibody. Accessed 26 Nov. 2024.

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Medical Definition

monoclonal antibody

noun
: an antibody that is derived from the clone of a single B cell and that is produced in large quantities of identical cells possessing affinity for the same epitope on a specific antigen (as a cancer cell)

Note: Monoclonal antibodies are typically used in immunotherapy (such as in the treatment of autoimmune or inflammatory disorders and cancer), diagnostic testing, and cell identification and tracing. Hybridoma cell lines are typically employed to produce an unlimited supply of monoclonal antibodies.

Monoclonal antibodies have largely been applied clinically to the diagnosis and therapy of cancer and the modulation of the immune response to produce immunosuppression for treatment of autoimmune and graft versus host diseases (GVHD) and for prevention of allograft rejection.—Thomas A. Walmann, Science
Monoclonal antibodies can distinguish and single out a specific protein from the other molecules around it. Monoclonal antibodies are versatile and can assist in the identification, tracking, and alteration of specific proteins.—Maryann Bozzette, Journal of Perinatal & Neonatal Nursing
—abbreviation MAb, mAb, MAB, mab
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