SSRI

noun

ˌes-(ˌ)es-(ˌ)är-ˈī How to pronounce SSRI (audio)
: any of a class of antidepressants (such as fluoxetine) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic neuron endings

called also selective serotonin reuptake inhibitor

Examples of SSRI in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Drug-drug interactions concerning Zoloft, a selective serotonin reuptake inhibitor (SSRI), mainly cause an increase of the neurotransmitter serotonin in the body. — Karen Berger, Pharmd, Verywell Health, 20 Feb. 2025 Understanding Lexapro and Its Effects Lexapro is a medication in the SSRI family. — Megan Nunn, Verywell Health, 12 Feb. 2025

Word History

First Known Use

1991, in the meaning defined above

Time Traveler
The first known use of SSRI was in 1991

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SSR
SSRI
SSS
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Cite this Entry

“SSRI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/SSRI. Accessed 8 Apr. 2025.

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Medical Definition

SSRI

noun
ˌes-(ˌ)es-(ˌ)är-ˈī How to pronounce SSRI (audio)
: any of a class of antidepressants (as fluoxetine or sertraline) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic nerve cell endings

called also selective serotonin reuptake inhibitor

compare snri
Last Updated: - Updated example sentences
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